Endocrine Abstracts

Introduction: Relative adrenal insufficiency (RAI) is common in critically ill patients and is characterized by the normal adrenal reserve for homeostatic demands and inadequate cortisol response in acute stress situations. RAI can also occur in patients with liver cirrhosis, both compensated and decompensated. However, it is often forgotten and difficult to diagnose due to the overlap between clinical symptoms of adrenal insufficiency and decompensated liver disease. Also, hy...

Introduction: It is well documented that adrenal tumor tissue is responsive to human chorionic gonadotropin (hCG) as well as to luteinizing hormone (LH) with both hormones sharing a similar physiological role and a mutual receptor.Objective: The objective of our study was to assess the adrenal steroid response to acute, exogenous hCG stimulation in patients with adrenal incidenatalomas (AI) and for the first time, in a healthy control group.<p class=...

Introduction: The interplay between obesity and hormones has a profound impact on women’s reproductive health, reducing the likelihood of successful conception.Methods: We performed a 6-month longitudinal study. The inclusion criteria were: women aged 20-40 with infertility, regular anovulatory menstrual cycles, BMI 35-40 kg/m², unrelated to other diseases. 30 eligible women were categorized into three groups: Group 1 (G1) received motivational...

Corticotroph Pituitary Neuroendocrine Tumours (Co-PitNETs) show significant differences in cortisol secretion, responses to existing therapies and gene expression andstill pose a challenge for patient management.Aim: to explore possible novel therapeutic targets in Co-PitNETs (functioning and silent) through transcriptome analysis (RNA sequencing) and immunohistochemistry. Methods: Transcriptomic data from a previously reported dat...

Introduction: The prevalence of adrenal incidentalomas (AI) and renal cysts increase with age. Depending on the study population age and sex, on average, both are prevalent with about 8 to 10% in subjects older than 50 years of age.Aim: We aimed to investigate the co-occurrence of AI and simple renal cysts.Methods: Our study included 970 subjects, 494 with AI – all evaluated in single centre, and 476 control group (CG) patien...

Introduction: It has been shown that women with a previous Sars-CoV-2 infection have long-lasting menstrual cycle (MC) changes.Aim: To investigate the MC changes and their relationship with women’s reproductive, sexual and mental health disturbances during the COVID-19 pandemic.Methods: Anonymous survey about reproductive, sexual and mental health was shared with women of reproductive age between May 2022 and November 2023. Al...